It Runs in the Family

Genetic genealogy is the application of genetics to traditional genealogy. Genetic genealogy involves the use of genealogical DNA testing to determine the level and type of the genetic relationship between individuals.
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darkerhorse
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It Runs in the Family

Post by darkerhorse »

Husband and wife are 3rd cousins to each other on the same surname line from the same town in Sicily.

Surname males on the husband's side have a disproportionately high incidence of a particular disease - "it runs in the family" - but not on the wife's side.

In the absence of DNA testing, can any hypotheses be drawn about who it comes from?
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MarcuccioV
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Re: It Runs in the Family

Post by MarcuccioV »

My guess is the carrier (of the gene tied to the disease in males) is a female spouse on the husband's side. But that's merely a guess...
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darkerhorse
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Re: It Runs in the Family

Post by darkerhorse »

As I think of it, three examples come to mind - all born in the 1920s or 1930s. They were cousins to each other, sharing the same set of surname grandparents. Their grandmother might be the common denominator. Her female ancestor also married into the family.
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